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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple id="role_body"><p>Sent via BlackBerry by AT&T</p><hr/><div><b>From: </b> "Kathy Keatley Garvey" &lt;kegarvey@ucdavis.edu&gt;
</div><div><b>Date: </b>Tue, 27 Sep 2011 10:05:02 -0700</div><div><b>To: </b>&lt;Ladadams@aol.com&gt;</div><div><b>Subject: </b>Study of bees links gene regulatory networks in the brain to behavior</div><div><br/></div><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Here&#8217;s something of interest<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><a href="http://www.eurekalert.org/pub_releases/2011-09/uoia-sob092311.php">http://www.eurekalert.org/pub_releases/2011-09/uoia-sob092311.php</a><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p>&nbsp;</o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p>&nbsp;</o:p></span></p><p class=MsoNormal><b>Public release date: 26-Sep-2011</b><br>[ <a href="http://www.eurekalert.org/pub_releases/2011-09/uoia-sob092311.php" target="_self">Print</a> | <a href="http://www.eurekalert.org/pub_releases/2011-09/uoia-sob092311.php" target="_self">E-mail</a> | <a href="http://www.addthis.com/bookmark.php?v=20"><span style='color:windowtext;text-decoration:none'><span style='color:blue'><img border=0 width=11 height=11 id="Picture_x0020_3" src="cid:image001.gif@01CC7CFC.EC1B59C0" alt=Share></span></span>Share</a> ] [ <a href="http://www.eurekalert.org/pub_releases/2011-09/uoia-sob092311.php" target="_self">Close Window</a> ] <br><br>Contact: Diana Yates<br><a href="mailto:diya@illinois.edu">diya@illinois.edu</a><br>217-333-5802<br><a href="http://www.uiuc.edu">University of Illinois at Urbana-Champaign</a> <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-size:24.0pt'>Study of bees links gene regulatory networks in the brain to behavior<o:p></o:p></span></b></p><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=right width=218 style='width:163.5pt'><tr><td colspan=5 style='padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=1 height=10 id="Picture_x0020_4" src="cid:image002.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td></tr><tr style='height:3.0pt'><td style='padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_5" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td width=4 valign=top style='width:3.0pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=4 id="Picture_x0020_6" src="cid:image004.jpg@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/corner_tl.jpg"><o:p></o:p></p></td><td width=210 style='width:157.5pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=1 height=10 id="Picture_x0020_7" src="cid:image002.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td width=4 valign=top style='width:3.0pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal align=right style='text-align:right;mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=4 id="Picture_x0020_8" src="cid:image005.jpg@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/corner_tr.jpg"><o:p></o:p></p></td><td style='padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_9" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td></tr><tr><td style='padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_10" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td style='background:#F2F2F2;padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=1 id="Picture_x0020_11" src="cid:image006.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td style='background:#F2F2F2;padding:0in 0in 0in 0in'><p class=MsoNormal align=center style='text-align:center;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><a href="http://www.eurekalert.org/multimedia/pub/36285.php?from=194769" target="_self"><span style='text-decoration:none'><img border=0 width=200 height=280 id="Picture_x0020_12" src="cid:image007.jpg@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/multimedia/pub/rel/36285_rel.jpg"></span></a><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><a href="http://www.eurekalert.org/multimedia/pub/36285.php?from=194769" target="_self"><span style='color:windowtext;text-decoration:none'><span style='color:blue'><img border=0 width=16 height=12 id="Picture_x0020_13" src="cid:image008.gif@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/eutube/icon_image_tiny.gif"></span></span><b><span style='color:black'>IMAGE:</span></b></a> University of Illinois Institute for Genomic Biology director Gene Robinson and his colleagues found a &#8220;mosaic&#8221; pattern of behavior-related gene expression in the brain.<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><a href="http://www.eurekalert.org/multimedia/pub/36285.php?from=194769" target="_self">Click here for more information.</a> <o:p></o:p></p></td><td style='background:#F2F2F2;padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=1 id="Picture_x0020_14" src="cid:image006.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td style='padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_15" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td></tr><tr style='height:3.0pt'><td style='padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_16" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td width=4 valign=bottom style='width:3.0pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=4 id="Picture_x0020_17" src="cid:image009.jpg@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/corner_bl.jpg"><o:p></o:p></p></td><td width=202 style='width:151.5pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=1 height=10 id="Picture_x0020_18" src="cid:image002.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td><td width=4 valign=bottom style='width:3.0pt;background:#F2F2F2;padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal align=right style='text-align:right;mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=4 height=4 id="Picture_x0020_19" src="cid:image010.jpg@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/corner_br.jpg"><o:p></o:p></p></td><td style='padding:0in 0in 0in 0in;height:3.0pt'><p class=MsoNormal style='mso-line-height-alt:3.0pt;mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=8 height=1 id="Picture_x0020_20" src="cid:image003.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td></tr><tr><td colspan=5 style='padding:0in 0in 0in 0in'><p class=MsoNormal style='mso-element:frame;mso-element-frame-hspace:2.25pt;mso-element-wrap:around;mso-element-anchor-vertical:paragraph;mso-element-anchor-horizontal:column;mso-element-left:right;mso-element-top:middle;mso-height-rule:exactly'><img border=0 width=1 height=10 id="Picture_x0020_21" src="cid:image002.png@01CC7CFC.EC1B59C0" alt="http://www.eurekalert.org/images/clear.gif"><o:p></o:p></p></td></tr></table><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>CHAMPAIGN, Ill. &#8212; A new study reveals that distinct networks of genes in the honey bee brain contribute to specific behaviors, such as foraging or aggression, researchers report.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The study, in the <i>Proceedings of the National Academy of Sciences, </i>is the first to show that common, naturally occurring behaviors are under the influence of discrete regulatory networks in the brain. It confirms, scientists say, what years of research into the brain and behavior seemed to indicate: There is a close relationship between changes in gene expression &#8211; which genes are actively transcribed into other molecules to perform specific tasks in the cell &#8211; and behavior.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>&quot;We found that there is a high degree of modularity in the regulation of genes and behavior, with distinct behavioral states represented by distinct gene network configurations,&quot; said University of Illinois <a href="http://www.life.illinois.edu/entomology/">entomology</a> and <a href="http://neuroscience.illinois.edu/redirected.html">neuroscience</a> professor <a href="http://www.igb.illinois.edu/about/director">Gene Robinson</a>, who led the study. Robinson is the director of the <a href="http://www.igb.illinois.edu/">Institute for Genomic Biology</a> at Illinois.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The study made use of data from the <a href="http://www.beespace.uiuc.edu/">BeeSpace Project</a>. Curated by Illinois <a href="http://www.med.illinois.edu/depts%5Fprograms/sciences/basic/MedInfoSci/">medical information science</a> professor <a href="http://www.canis.uiuc.edu/schatz.html">Bruce Schatz</a>, BeeSpace is a catalog of genes that turn on or off in the bee brain in response to social cues, environmental changes or as a result of hereditary factors. By analyzing gene expression and behavioral data from dozens of studies (which were performed under the auspices of the BeeSpace Project), the researchers were able to get a broad view of the molecular changes in the bee brain that contribute to behavior.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The team focused their analysis on lists of genes implicated in at least one of three categories of behavior: foraging, such as scouting for flowers or navigating to and from the hive; maturation, the process by which an adult honey bee graduates from being a nanny to working as a forager as it grows older; and aggression, or hive defense.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The researchers then used a systems approach, led by Illinois chemical and biomolecular engineering professor <a href="http://price.systemsbiology.net/">Nathan Price</a> (now at the Institute for Systems Biology in Seattle), to create a computer model of a gene regulatory network that could predict the differences in gene expression seen in the experimental studies.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The model found a &quot;mosaic&quot; pattern of behavior-related gene expression in the brain. It also predicted that a few transcription factors &#8211; genes that regulate other genes &#8211; play a role in all three behavioral categories. Only four of these &quot;global regulators&quot; were identified, while sets of about 15-25 transcription factors were behavior-specific.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>Researchers have long worried that the regulation of brain gene expression is too complex to fathom, because so many factors can act together to regulate behavior.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>&quot;But now we see that direct, linear relationships between transcription factors and downstream genes can predict a surprisingly large amount of gene expression,&quot; Price said. &quot;This gives scientists hope that it will be possible to completely understand the regulation of brain gene expression in the future.&quot;<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'>###<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>Funding for this study was provided by the National Science Foundation, the National Institutes of Health, the National Cancer Institute, the U.S. Department of Defense, the Grand Duchy of Luxembourg and the Roy J. Carver Charitable Trust.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>Editor's notes: To reach Gene Robinson, call 217- 265-0309; email generobi@illinois.edu.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'>The paper, &quot;Behavior-Specific Changes in Transcriptional Modules Lead to Distinct and Predictable Neurogenomic States,&quot; is available from the U. of I News Bureau.<o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p>&nbsp;</o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p>&nbsp;</o:p></span></p><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D'>Kathy Keatley Garvey<br>Communications Specialist<br>Department of Entomology<br>372 Briggs Hall<br>One Shields Ave.<br>University of California, Davis<br>Davis, CA 95616<br>Phone: (530) 754-6894<br>Fax: (530) 752-1537<br><a href="mailto:kegarvey@ucdavis.edu" title="blocked::mailto:kegarvey@ucdavis.edu">kegarvey@ucdavis.edu</a></span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>&nbsp;<br>UC Davis Department of Entomology website:<br></span><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:#1F497D'><a href="http://entomology.ucdavis.edu/home.cfm" title="blocked::http://entomology.ucdavis.edu/home.cfm">http://entomology.ucdavis.edu/home.cfm</a><br>Harry H. Laidlaw Jr. Honey Bee Research Facility website:<br><a href="http://beebiology.ucdavis.edu">http://beebiology.ucdavis.edu</a><br>UC Agriculture and Natural Resources website:<br><a href="http://ucanr.org/index.cfm">http://ucanr.org/index.cfm</a><br>Bug Squad Blog<br><a href="http://ucanr.org/blogs/bugsquad/">http://ucanr.org/blogs/bugsquad/</a><br>Flickr Photos </span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><br><a href="http://www.flickr.com/photos/pho-tog/">http://www.flickr.com/photos/pho-tog/</a></span><span style='color:#1F497D'><o:p></o:p></span></p></div><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p>&nbsp;</o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> pollinator-bounces+kegarvey=ucdavis.edu@lists.sonic.net [mailto:pollinator-bounces+kegarvey=ucdavis.edu@lists.sonic.net] <b>On Behalf Of </b>Ladadams@aol.com<br><b>Sent:</b> Friday, September 16, 2011 5:10 PM<br><b>To:</b> pollinator@nappc.org<br><b>Subject:</b> [Pollinator] Fwd: opening of Agriculture Museum in Santa Paula<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p>&nbsp;</o:p></p><div><blockquote style='border:none;border-left:solid blue 1.5pt;padding:0in 0in 0in 4.0pt;margin-left:3.75pt;margin-top:5.0pt;margin-bottom:5.0pt'><div><div class=MsoNormal align=center style='text-align:center'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><hr size=2 width="100%" align=center></span></div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>From: rhozbud@sbcglobal.net<br>To: LDA@pollinator.org<br>Sent: 9/16/2011 2:10:18 P.M. Pacific Daylight Time<br>Subj: opening of Agriculture Museum in Santa Paula<o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>&nbsp;<o:p></o:p></span></p></div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>hi Laurie, <o:p></o:p></span></p><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>Hope this finds you well. Just wanted to let you know about this exhibition, featuring some of my bee images.<o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.venturamuseum.org/AgricultureMuseum/tabid/289/Default.aspx" title="http://www.venturamuseum.org/AgricultureMuseum/tabid/289/Default.aspx">http://www.venturamuseum.org/AgricultureMuseum/tabid/289/Default.aspx</a><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>all the best,<o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>Rose-Lynn<o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><a href="http://www.rose-lynnfisher.com/" title="http://www.rose-lynnfisher.com/">www.rose-lynnfisher.com</a><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'><o:p>&nbsp;</o:p></span></p></div></blockquote></div></div></body></html>